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Student Research Symposium

The annual symposium program will feature both oral and poster presentations given by undergraduate and graduate students conducting research at local universities within New Haven County. Presentation topics will cover research in fields such as pharmaceuticals, nanotechnology, analytical chemistry, forensics, biochemistry, polymer science, green chemistry and sustainability. If you are interested in presenting or attending, please fill out the form below. Note: Registrants will be given information regarding free parking.

Keynote Speaker

Craig M. Crews

Departments of Molecular, Cell and Developmental Biology; Chemistry; and Pharmacology, Yale University, New Haven, CT, USA

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PROTAC-mediated Protein Degradation: A New Therapeutic Modality

Enzyme inhibition has proven to be a successful paradigm for pharmaceutical development, however, it has several limitations.  As an alternative, for the past 16 years, my lab has focused on developing Proteolysis Targeting Chimera (PROTAC), a new ‘controlled proteolysis’ technology that overcomes the limitations of the current inhibitor pharmacological paradigm. Based on an ‘Event-driven’ paradigm, PROTACs offer a novel, catalytic mechanism to irreversibly inhibit protein function, namely, the intracellular destruction of target proteins. This approach employs heterobifunctional molecules capable of recruiting target proteins to the cellular quality control machinery, thus leading to their degradation.   We have demonstrated the ability to degrade a wide variety of targets (kinases, transcription factors, epigenetic readers) with PROTACs at picomolar concentrations.  Moreover, the PROTAC technology has been demonstrated with multiple E3 ubiquitin ligases, included pVHL and cereblon.

Registration Form

Name *
Name
Attendee Type *
Year *
If public write employer.
Are you an ACS Member? *
Would you like to learn more about ACS-NH? *
Preferred Presentation Type *
If not student, select N/A If poster, 3 feet by 4 feet / If oral, 15 minute presentation
Maximum of 20 words.
Maximum of 250 words

Date/Time:

April 13th, 2019 / 8:15 AM-3 PM

Location:

Sterling Chemistry Lab
Yale University

225 Prospect Street
New Haven, CT 06511

 
 

Tentative Schedule:

8:15-9:00 Registration and Breakfast  (Second floor of SCLl)

9:00-9:10 Welcome and Introductions

9:10-10:00 Keynote Speaker -  SCL 110

10:00-10:15 Break (Coffee and leftovers)  (2nd floor)

10:15-11:40 Oral presentations (SCL 110)

11:45 - 12:30 Lunch (Second floor of SCL)

12:30-1:30 Poster Session (Second floor of SCL) (Coffee out during the poster session)

1:30-2:30 Industry Panel Event (SCL 110)

2:30-3:00 Award Ceremony

3:00 Symposium closes